Sons de canari5/7/2023 Malocello made landfall (possibly shipwrecked) on Lanzarote island, and remained there for nearly twenty years. Malocello's motives were unclear - it is believed he might have been searching for traces of the Vivaldi brothers who had disappeared off Morocco, around Cape Non back in 1291. The first visit by a European to the Canary Islands since antiquity was by Genoese captain Lanceloto Malocello traditionally dated 1312 (but probably a little later, between 1318–1325). In the following century, Castile and Portugal were the primary contenders. In the 14th century, a variety of forces competed for control of the Canaries: Genoese, Majorcan, Portuguese and Castilian. Main article: Canary Islands in pre-colonial times For this reason, territorial expansion represented a reinforcement of royal power, imbued with crusader and missionary spirit. In the case of the Iberian monarchies, their territorial expansion was spurred by the reconquista ("reconquest") of Moorish southern Spain ( al-Andalus). Ideological and political motives: the monarchies of Southern Europe entered an expansive phase.The first expedition to visit all the islands of the archipelago took place two years later, in 1341, under the command of fellow Genoese seaman and explorer Niccoloso da Recco, at the service and on behalf of Portuguese king Afonso IV. Development of new navigation techniques ( compass, astrolabe, stern rudder, cog- caravel) and the development of cartography: a portulan map by Angelino Dulcert of Majorca, from 1339, is the first to show some of the Canary Islands, and this date might in fact coincide with the effective rediscovery of the islands by the Genoese seaman Lanzarotto Malocello.These states were already engaging in maritime trade along the Moroccan coast. The economic expansion of some European states, such as the Republic of Genoa, the Kingdom of Aragon, the Kingdom of Castille, and the Kingdom of Portugal.Visits to the archipelago began to increase after the end of the 13th century for reasons including: What does seem clear is that this knowledge of the islands did not signify the end of the cultural isolation of the native inhabitants. ![]() During the Middle Ages, the first reports on the Canaries come from Arabic sources, which refer to some Atlantic islands which may have been the Canaries. Although these linkages were weakened, they were not totally severed, and the Canaries' isolation was not total. The ties between the Canaries and the Mediterranean world which had existed since antiquity were interrupted by the decline and fall of the Western Roman Empire. It can be divided into two periods: the Conquista señorial, carried out by Castilian nobility in exchange for a covenant of allegiance to the crown, and the Conquista realenga, carried out by the Spanish crown itself, during the reign of the Catholic Monarchs. The conquest of the Canary Islands by the Crown of Castille took place between 14, representing what some historians have labelled a genocide and described as the first instance of European settler colonialism in Africa. Banda Oriental and Rio Grande do Sul (1762–63).Iberian Peninsula and South America (1762–63).The CANARI study investigated in a population of men treated for BPH the risk of PCa with 5-ARI, according to Gleason grade thanks to SNIIRAM database enriched by local pathological results. We matched 859 cases to Gleason grading (119 had Gleason score ≥8 and 740 had Gleason <8) around 22% of cases received 5-ARI and 78% α-blockers or phytotherapy. No unique identification number is available in France linkage of SNIIRAM and Brittany pathology laboratories database was made by deterministic matching. Local pathology laboratories database was constituted in Brittany, gathering Gleason scores. ![]() Controls were patients without PCa diagnosis. Gleason score was searched through Brittany pathology laboratories. Cases were patients with incident PCa diagnosed between 20 identified through French Health database (SNIIRAM). We designed a case–control study nested within a cohort of men treated by medical drugs licensed for symptomatic BPH between 20. The study concerned patients living in the Brittany region (France) between 20. This paper focuses on describing the protocol of the CANARI study and its feasibility, as regards the matching process of two pseudo-anonymous databases. Later observational studies failed to show similar results but have some limits. Two clinical trials investigating 5-ARI use in prostate cancer (PCa) primary prevention highlighted a potential safety signal with an increased risk of high-grade PCa. ![]() Benign prostate hypertrophy (BPH) could be associated with low urinary symptoms requiring medical treatment: 5-alpha-reductase inhibitors (5-ARI) or ɑ-blockers.
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